67 research outputs found
Measuring a population of spin waves from the electrical noise of an inductively coupled antenna
We study how a population of spin waves can be characterized from the
analysis of the electrical microwave noise delivered by an inductive antenna
placed in its vicinity. The measurements are conducted on a synthetic
antiferromagnetic thin stripe covered by a micron-sized antenna that feeds a
spectrum analyser after amplification. The antenna noise contains two
contributions. The population of incoherent spin waves generates a fluctuating
field that is sensed by the antenna: this is the "magnon noise". The antenna
noise also contains the contribution of the electronic fluctuations: the
Johnson-Nyquist noise. The latter depends on all impedances within the
measurement circuit; this includes the antenna self-inductance. As a result,
the electronic noise contains information about the magnetic susceptibility,
though it does not inform on the absolute amplitude of the magnetic
fluctuations. For micrometer-sized systems at thermal equilibrium, the
electronic noise dominates and the pure magnon noise cannot be determined. If
in contrast the spinwave bath is not at thermal equilibrium with the
measurement circuit, and if the spinwave population can be changed then one
could measure a mode-resolved effective magnon temperature provided specific
precautions are implemented
Parametrizations of Inclusive Cross Sections for Pion Production in Proton-Proton Collisions
Accurate knowledge of cross sections for pion production in proton-proton
collisions finds wide application in particle physics, astrophysics, cosmic ray
physics and space radiation problems, especially in situations where an
incident proton is transported through some medium, and one requires knowledge
of the output particle spectrum given the input spectrum. In such cases
accurate parametrizations of the cross sections are desired. In this paper we
review much of the experimental data and compare to a wide variety of different
cross section parametrizations. In so doing, we provide parametrizations of
neutral and charged pion cross sections which provide a very accurate
description of the experimental data. Lorentz invariant differential cross
sections, spectral distributions and total cross section parametrizations are
presented.Comment: 32 pages with 15 figures. Published in Physical Review D62, 094030.
File includes 6 tex files. The main file is paper.tex which has include
statements refering to the rest. figures are in graphs.di
Tungsten oxide thin film for room temperature nitrogen dioxide gas sensing
Tungsten oxide (WO3) thin films for gas sensing have been successfully deposited using reactive direct current (DC) magnetron sputtering at different deposition temperatures (300 °C, 400 °C and 500 °C). The structural, morphological properties, thickness and composition have been investigated using X-ray diffraction (XRD), scanning electron microscopy (SEM) and Rutherford backscattering spectrometry (RBS) techniques. To investigate the effect of deposition temperature on the gas sensing properties of deposited thin films on alumina substrates, was conducted using the Kenosistec gas sensing unit. WO3 thin film deposited at 500 °C exhibited a higher response when sensing Nitrogen dioxide (NO2) at room temperature as compared to the thin films prepared at 300 °C and 400 °C, respectively. However, as deposited WO3 thin films exhibited low sensitivity when sensing reducing gases such as hydrogen (H2) and ammonia (NH3), which was an indication of good selectivity properties of WO3 related sensors
Sensitivity of IFN-γ Release Assay to Detect Latent Tuberculosis Infection Is Retained in HIV-Infected Patients but Dependent on HIV/AIDS Progression
BACKGROUND: Detection and treatment of latent TB infection (LTBI) in HIV infected individuals is strongly recommended to decrease morbidity and mortality in countries with high levels of HIV. OBJECTIVE: To assess the validity of a newly developed in-house ELISPOT interferon-gamma release assay (IGRA) for the detection of LTBI amongst HIV infected individuals, in comparison with the Tuberculin Skin Test (TST). METHODOLOGY/PRINCIPAL FINDINGS: ESAT6/CFP10 (EC) ELISPOT assays were performed, together with a TST, in 285 HIV infected individuals recruited in HIV clinics in Dakar, Senegal, who had no signs of active TB at time of enrolment. Thirty eight of the subjects (13.3%) failed to respond to PHA stimulation and were excluded from the analysis. In the 247 remaining patients, response to PHA did not vary according to CD4 cell count categories (p = 0.51). EC ELISPOT was positive in 125 (50.6%) subjects, while 53 (21.5%) had a positive TST. Concordance between EC ELISPOT and TST was observed in 151 patients (61.1%) (kappa = 0.23). The proportion of subjects with a positive response to the EC ELISPOT assay decreased with declining CD4 counts (p trend = 0.001), but were consistently higher than the proportion of TST responders. In multivariate analysis, the risk of being EC-ELISPOT positive in HIV infected individuals was associated with age, CD4 count and HIV-1 strain. CONCLUSION: Our study indicates that IGRAs using M. tuberculosis specific antigens are likely to retain their validity for the diagnosis of LTBI among HIV positive individuals, but may be impaired by T-cell anergy in severely immuno-suppressed individuals
A Simple, Inexpensive Device for Nucleic Acid Amplification without Electricity—Toward Instrument-Free Molecular Diagnostics in Low-Resource Settings
Molecular assays targeted to nucleic acid (NA) markers are becoming increasingly important to medical diagnostics. However, these are typically confined to wealthy, developed countries; or, to the national reference laboratories of developing-world countries. There are many infectious diseases that are endemic in low-resource settings (LRS) where the lack of simple, instrument-free, NA diagnostic tests is a critical barrier to timely treatment. One of the primary barriers to the practicality and availability of NA assays in LRS has been the complexity and power requirements of polymerase chain reaction (PCR) instrumentation (another is sample preparation).In this article, we investigate the hypothesis that an electricity-free heater based on exothermic chemical reactions and engineered phase change materials can successfully incubate isothermal NA amplification assays. We assess the heater's equivalence to commercially available PCR instruments through the characterization of the temperature profiles produced, and a minimal method comparison. Versions of the prototype for several different isothermal techniques are presented.We demonstrate that an electricity-free heater based on exothermic chemical reactions and engineered phase change materials can successfully incubate isothermal NA amplification assays, and that the results of those assays are not significantly different from ones incubated in parallel in commercially available PCR instruments. These results clearly suggest the potential of the non-instrumented nucleic acid amplification (NINA) heater for molecular diagnostics in LRS. When combined with other innovations in development that eliminate power requirements for sample preparation, cold reagent storage, and readout, the NINA heater will comprise part of a kit that should enable electricity-free NA testing for many important analytes
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